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Four of the GLP-1RAsalbiglutide, dulaglutide, semaglutide, and liraglutideare GLP-1 analogs, modified from the native structure of GLP-1, while exenatide and lixisenatide are based on the peptide exendin (a hormone derived from the saliva of the Gila monster), which has a similar structure to that of GLP-1 and retains GLP-1 activity [4]